支氣管擴張症

支氣管擴張症（Bronchiectasis）是一種慢性且逐步惡化的呼吸道發炎性疾病，其主要特徵為氣道永久性擴張，導致黏液無法正常排出。過度的黏液堆積不僅阻礙氣流通暢，也使患者更容易罹患反覆性的肺部感染。感染與發炎交互作用，形成氣道功能障礙、慢性發炎、感染與結構性肺損傷相互惡化的「惡性循環」，使病情持續進展。此疾病可見於多種潛在病因的患者之中，例如囊性纖維化（CF）、原發性纖毛運動障礙症（PCD）、類風濕性關節炎等發炎性疾病，或氣喘與慢性阻塞性肺病（COPD）等慢性肺部疾病。然而，約有半數患者的病因仍無法確定，稱為特發性支氣管擴張症。患者常出現長期咳嗽與大量痰液分泌等症狀，嚴重影響日常生活品質。目前仍迫切需要更有效的治療方式，以改善支氣管擴張症患者未被滿足的醫療需求。

Bronchiectasis is a progressive inflammatory respiratory disease characterized by irreversible enlarged airways, which prevent proper mucus clearance. This excessive mucus build up increases the risk of lung infections, leading to a continuous cycle of airway dysfunction, chronic inflammation, infection, and progressive structural lung damage, known as the 'vicious vortex'. The disease can occur in patients with various underlying conditions, such as cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), inflammatory diseases like rheumatoid arthritis, or chronic lung diseases like asthma and COPD. However, in up to 50% of cases, the cause remains unknown (idiopathic bronchiectasis). Bronchiectasis symptoms include coughing and production of large volumes of sputum, which can greatly impact quality of life. Effective bronchiectasis treatments are needed to address the existing high unmet need for those living with this disease.

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什麼是支氣管擴張症？

進一步了解支氣管擴張症的科學基礎、症狀以及尚未被滿足的醫療需求。

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